Beilstein J. Org. Chem.2021,17, 2321–2328, doi:10.3762/bjoc.17.150
University, Haikou 571199, Hainan Province, P. R. China 10.3762/bjoc.17.150 Abstract A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substitutedoxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate
recently as precursors in Friedel–Crafts reactions of arenes [30][31] and cross-coupling reactions of arylboronic reagents [32]. However, the direct SN1 reaction of such isatin-derived 3-phosphate-substitutedoxindoles by halide ions as nucleophiles has not been developed yet and remains an unsolved
summary, a new method for the synthesis of 3-monohalooxindoles via acidolysis of isatin-derived 3-phosphate-substitutedoxindoles with haloid acids was developed. The present methodology involves the formation of an oxindole having a phosphate moiety at the C-3 position via the [1,2]-phospha-Brook
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Graphical Abstract
Figure 1:
Representation of bioactive molecules and applications.